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Bioinformatics-based screening of key genes between maternal preeclampsia and offspring schizophrenia

Jiashuo Zhang1, Yangxue Yin2, Yijie Gao2

  • 1Department of Obstetrics and Gynecology, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China; Mental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Biochemical and Biophysical Research Communications
|May 21, 2022
PubMed

Insights

Maternal preeclampsia is linked to increased schizophrenia risk in offspring. This study identified key genes, CKAP5 and SAT1, involved in metabolism, offering insights into this neurodevelopmental connection.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Schizophrenia is associated with prenatal neurodevelopmental disorders.
  • Preeclampsia during pregnancy increases offspring risk for abnormal neurodevelopment.
  • The molecular mechanisms linking maternal preeclampsia to offspring schizophrenia are not fully understood.

Purpose of the Study:

  • To identify key protein-coding genes associated with both maternal preeclampsia and offspring schizophrenia.
  • To investigate the expression patterns of these genes in neural cells.
  • To explore potential molecular pathways involved in the observed association.

Main Methods:

  • Analysis of Gene Expression Omnibus (GEO) datasets (GSE53987, GSE166846) to find common differentially expressed genes (DEGs) between preeclampsia and schizophrenia.
  • Examination of DEG expression in neural cells (GSE62105) and human neural stem cells (GSE92845).
  • Time-course analysis of selected DEGs (CKAP5, SAT1) in human neural stem cells and KEGG pathway analysis.

Main Results:

  • Ten common DEGs were identified between preeclampsia and schizophrenia.
  • All ten DEGs showed differential expression in neural cells of schizophrenic patients compared to controls.
  • CKAP5 and SAT1 expression levels significantly differed in human neural stem cells at day 30 compared to day 0.
  • KEGG pathway analysis indicated involvement in metabolic pathways.

Conclusions:

  • This study identified potential key genes, CKAP5 and SAT1, linking maternal preeclampsia to offspring schizophrenia.
  • These genes, involved in metabolism, show altered expression in neural stem cells, suggesting a role in neurodevelopmental pathways.
  • Findings provide novel insights into the genetic basis of the association between preeclampsia and schizophrenia risk.

Keywords:
BioinformaticsNeurodevelopmentPreeclampsiaSchizophrenia

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