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Serotonin Type 2a Receptor in the Prefrontal Cortex Controls Perirhinal Cortex Excitability During Object Recognition

J F Morici1, G Cicuttin1, A Silva2

  • 1Instituto de Neurociencia Cognitiva y Traslacional, Concejo Nacional de Investigaciones Científicas y tecnológicas (CONICET), Universidad Favaloro, Instituto de Neurología Cognitiva (INECO), Pacheco de Melo 1860, C1126AAB Buenos Aires, Argentina.

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Summary
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Blocking serotonin receptors in the medial prefrontal cortex (mPFC) enhances memory recall by increasing neuronal activity in the Perirhinal Cortex (PRH). This suggests mPFC serotonin 2a receptors (5-HT2aR) control memory retrieval via PRH activation.

Keywords:
Perirhinal Cortexc-Fosmedial Prefrontal Cortexrecognition memoryserotonin 2aR

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Molecular Psychiatry

Background:

  • Previous experiences shape adaptive behavior by utilizing contextual information for memory recall.
  • The medial prefrontal cortex (mPFC) is crucial for regulating memory retrieval in downstream brain regions.
  • Serotonin 2a receptors (5-HT2aR) in the mPFC influence memory retrieval and reconsolidation in the Perirhinal Cortex (PRH).

Purpose of the Study:

  • To investigate the mechanism by which mPFC 5-HT2aR activity modulates memory retrieval in the PRH.
  • To elucidate the role of mPFC 5-HT2aR in controlling neuronal activity within the mPFC and PRH during memory tasks.

Main Methods:

  • Combined behavioral analysis, pharmacological interventions (mPFC 5-HT2aR blockade), and immunohistochemistry (c-Fos expression) to measure neuronal activity.
  • Analyzed c-Fos expression in both the mPFC and PRH to assess neuronal activation.
  • Correlated neuronal activity with behavioral performance in a contextually guided recognition memory task.

Main Results:

  • Blockade of mPFC 5-HT2aR significantly increased c-Fos expression in the PRH, correlating with improved task performance.
  • mPFC 5-HT2aR blockade also increased c-Fos expression in the mPFC, but this did not correlate with behavioral outcomes.
  • Changes in mPFC neuronal activity showed a significant correlation with those observed in the PRH.

Conclusions:

  • mPFC 5-HT2aR signaling plays a critical role in modulating behavioral responses during memory recall.
  • The mPFC exerts its control over memory recall, in part, by regulating neuronal activation within the PRH.
  • These findings highlight a specific neural pathway through which serotonin influences memory processes.