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Updated: Sep 22, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Quantifying how drug-polymer interaction and volume phase transition modulate the drug release kinetics from
Poh Teck Lim1, Risky Muhamad Irwan1, Zhong Li2
1School of Engineering, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
Abstract:
This paper presents a simple experimental-informed theory describing the drug release process from a temperature-responsive core-shell microgel. In stark contrast to the commonly employed power-law models, we couple electric, hydrophobic, and steric factors to characterize the impact of drug-polymer pair interaction on the release kinetics. To this end, we also propose a characteristic time, depicting the drug release process as an interplay between kinetics and thermodynamics. In some instances, the negative correlation between the diffusivity and the (thermodynamics) drug-polymer interaction renders the drug release time non-trivial. In conclusion, our theory establishes a mechanistic understanding of the drug release process, exploring the effect of (hydrophobic adhesion) attractive and (steric exclusion) repulsive pair interactions between the drugs and the microgel in the presence of temperature-induced volume phase transition.
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