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Updated: Sep 22, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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PDE4D binds and interacts with YAP to cooperatively promote HCC progression

Huili Ren1, Yingxiang Chen1, Zhou Ao1

  • 1Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cancer Letters
|May 21, 2022
PubMed
Summary

Phosphodiesterase 4D (PDE4D) promotes hepatocellular carcinoma (HCC) by interacting with yes-associated protein (YAP). Targeting this PDE4D-YAP interaction with roflumilast may offer a new HCC treatment strategy.

Keywords:
Extracellular signal-regulated kinaseHepatocellular carcinomaPhosphodiesterase 4Yes-associated proteincAMP/PKA pathwayroflumilast

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