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Updated: Sep 22, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Should we consider calcimimetics as a therapeutic option for nephrotic syndrome?
Olivia Lenoir1, Pierre-Louis Tharaux1
1Paris Cardiovascular Center (PARCC), Institut de la Santé et de la Recherche Médicale (Inserm), Université Paris Cité, Paris, France.
Abstract:
Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Mühlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation of albuminuria and proteinuria was observed in 4 children treated with cinacalcet. Here we discuss the potential mechanisms whereby CaSR displays a favorable effect in podocytes and the context in which calcimimetics may alleviate nephrotic syndrome.
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