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Serum uric acid in patients with ST-segment elevation myocardial infarction: An innocent bystander or leading actor?
Vilma Kajana1, Gianluca Massaro2, Alberto Somaschini3
1Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Abstract:
Elevated serum uric acid (SUA) levels have been associated with several cardiovascular risk factors and the progression of coronary artery disease. In the setting of acute myocardial infarction, increasing evidence suggests that high SUA levels could be related to adverse outcomes. Interestingly elevated SUA levels have been linked to endothelial dysfunction, inflammation and oxidative stress. The aim of this review is to discuss the potential negative effects of SUA in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention, analyzing the possible underlying pathophysiological mechanisms.
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