Related Experiment Video
Updated: Sep 22, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
[Troponin-T and n-terminal pro-brain type natriuretic peptide plasma levels and its relationship with mortality in
A M Ghelfi1, B A Sánchez1, L A Berbotto1
1Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina.
Insights
Elevated amino-terminal fraction of pro-brain natriuretic peptide (NT-proBNP) levels at hospital admission indicate a higher mortality risk in patients with moderate-severe COVID-19. Troponin-T also showed increased risk, but NT-proBNP was an independent predictor.
Area of Science:
- Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- COVID-19 can cause subclinical cardiovascular compromise due to inflammation, cytokine storm, and endothelial dysfunction.
- Classic myocarditis symptoms are not always present in COVID-19 cardiovascular complications.
- Biomarkers like Troponin-T and NT-proBNP may indicate cardiac involvement in COVID-19 patients.
Purpose of the Study:
- To analyze the relationship between Troponin-T (TT) and NT-proBNP levels upon hospital admission and mortality in COVID-19 patients.
- To determine if these biomarkers are associated with in-hospital mortality in moderate-to-severe COVID-19 cases.
Main Methods:
- Retrospective cohort study of 108 hospitalized COVID-19 patients with moderate-to-severe illness.
- Measured TT (≥0.014 ng/dl) and NT-proBNP (≥300 pg/ml) within 24 hours of admission.
- Analyzed mortality rates in relation to elevated biomarker levels using univariate and multivariate analyses.
Main Results:
- 25% of patients died, and 28% were admitted to the Critical Care Unit.
- Elevated TT was associated with higher mortality (OR=3.1).
- Elevated NT-proBNP was also associated with higher mortality (OR=3.47) and remained an independent risk factor in multivariate analysis.
Conclusions:
- NT-proBNP levels ≥300 pg/ml at admission are a significant predictor of mortality in moderate-to-severe COVID-19.
- Elevated NT-proBNP is an independent risk factor for mortality in this patient population.
Introduction:
Cardiovascular compromise in coronavirus disease 2019 (COVID-19) does not necessarily present with the classic symptoms described in myocarditis. There is growing evidence demonstrating subclinical cardiovascular compromise in the context of the intense inflammation unleashed, the cytokine storm involved, the baseline prothrombotic state, and the consequent endothelial dysfunction. We set out to analyse whether Troponin-T (TT) and the amino-terminal fraction of pro-brain natriuretic peptide (NT-proBNP) determined at hospital admission, are related to mortality during the hospitalization of these patients.
Material And Methods:
Analytical, observational, retrospective cohort and cross-sectional study. It included subjects with COVID-19 hospitalized for moderate-severe illness, from 20/03/20 to 15/11/20. The TT and NT-proBNP obtained in the first 24 hours from admission were analysed. Altered TT was considered if ≥.014 ng/dl and altered NT-proBNP if ≥300 pg/ml.
Results:
One hundred and eight subjects were included, 63.2% men, age 51.5 years (59-43), 28% were admitted to the Critical Unit and 25% died. The group with elevated TT presented higher mortality (OR = 3.1; 95%CI = 1.10-8.85; p = .02). The group with elevated NT-proBNP also show higher mortality (OR = 3.47; 95%CI = 1.21-9.97; p = .01). On multivariate analysis, only NT-proBNP ≥300 pg/ml remained an independent risk factor.
Conclusions:
NT-proBNP levels ≥300 pg/ml at admission in patients with moderate-severe COVID-19 were associated with higher mortality.
More Related Videos
07:40Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
Published on: October 10, 2019
07:14Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
Published on: June 16, 2023
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:30Acute Coronary Syndrome I: Introduction
01:29Heart Failure II: Pathophysiology