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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

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664

Noncoding RNA actions through IGFs and IGF binding proteins in cancer

Aidan Kerr1, Robert C Baxter2

  • 1University of Sydney, Faculty of Medicine and Health, Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, NSW, 2065, Australia. aidan.kerr1998@gmail.com.

Oncogene
|May 21, 2022
PubMed

Insights

This review explores how noncoding RNAs (ncRNAs) interact with insulin-like growth factors (IGFs) and their binding proteins in cancer. Understanding these links may reveal new cancer prognosis and therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are crucial in cancer progression, affecting cell survival, proliferation, migration, angiogenesis, and metastasis.
  • IGFBPs regulate the bioavailability of IGF-1 and IGF-2, impacting the type-1 IGF receptor (IGF1R) pathway and influencing cancer development through IGF-dependent and independent mechanisms.
  • Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long-noncoding RNAs (lncRNAs), are involved in oncogenic pathways, but their intersections with the IGF axis in cancer are not fully understood.

Purpose of the Study:

  • To review the functional interactions between miRNAs and lncRNAs with IGFs and IGFBPs in the context of cancer.
  • To elucidate how the IGF axis mediates ncRNA actions that either promote or suppress cancer development.
  • To identify potential new avenues for cancer prognosis and therapeutic interventions by understanding the links between ncRNA and IGF pathways.

Main Methods:

  • Literature review and synthesis of existing research on ncRNAs, IGFs, and IGFBPs in cancer.
  • Analysis of functional interactions and signaling pathways involving these molecular players.
  • Exploration of intersecting pathways in non-cancer conditions to inform cancer research.

Main Results:

  • ncRNAs functionally interact with IGFs and their binding proteins, influencing cancer progression.
  • The IGF axis plays a role in mediating the pro-cancer or anti-cancer effects of ncRNAs.
  • Interactions between ncRNAs and the IGF axis are observed in various cancer types and may extend to non-cancerous conditions.

Conclusions:

  • A deeper understanding of ncRNA-IGF axis interactions is essential for developing novel cancer biomarkers and therapeutic strategies.
  • Exploring these pathways in both cancer and non-cancer conditions can uncover new opportunities for cancer control.
  • Targeting the interplay between ncRNAs and the IGF system holds promise for future cancer treatment advancements.

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