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Complex management of children affected with cleft lip and palate associated with genetic syndromes

Attila Vástyán1, Teodor Barna Maros2, Kinga Amália Sándor-Bajusz3

  • 11 Pécsi Tudományegyetem, Klinikai Központ, Általános Orvostudományi Kar, Gyermekgyógyászati Klinika, Manuális Tanszék Pécs, József Attila u 7., 7623 Magyarország.

Orvosi Hetilap
|May 22, 2022
PubMed

Insights

Facial cleft treatment requires modification for syndromic patients. Associated anomalies in genetic syndromes often take priority over cleft lip and palate reconstruction.

Area of Science:

  • Craniofacial Surgery
  • Pediatric Genetics
  • Developmental Biology

Background:

  • Facial clefts are common developmental anomalies, but can be associated with genetic syndromes.
  • Syndromic clefts present unique challenges compared to isolated cases.

Purpose of the Study:

  • To analyze the treatment of syndromic cleft patients.
  • To determine if standard treatment algorithms need modification for syndromic cases.

Main Methods:

  • Retrospective analysis of 1999-2015 Pecs Cleft Team patient data.
  • Inclusion of surgical, genetic, and national registry epidemiological data.

Main Results:

  • 607 patients treated; 25 (4.11%) had anomalies, 16 (2.6%) had syndromes.
  • Robin sequence was the most common syndrome (50%).
  • 13 patients required modified treatment algorithms due to genetic syndromes.

Conclusions:

  • Genetic syndromes significantly impact cleft lip and palate treatment algorithms.
  • Prioritizing surgical treatment of associated anomalies is crucial in syndromic cases.

Keywords:
ajakhasadékcleft lipcleft palatecomplex treatmentgenetic syndromegenetikai szindrómakomplex kezelésszájpadhasadék

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