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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
TRPC6 is altered in COVID-19 pneumonia
Gina Leidinger1, Fidelis Flockerzi2, Johannes Hohneck2
1Institute of Anatomy and Cell Biology, Saarland University, Homburg, Saar, Germany.
TRPC6 protein, a transient receptor potential channel, is present in normal human lungs and altered in COVID-19 pneumonia lungs. This suggests TRPC6 may worsen SARS-CoV-2 inflammation and could be a therapeutic target.
Area of Science:
- Pulmonary Medicine
- Molecular Biology
- Immunology
Background:
- Transient Receptor Potential (TRP) channels are implicated in COVID-19 pneumonia, yet their protein expression in lung tissue remains underreported.
- TRP channels are hypothesized to contribute to pulmonary inflammation and associated symptoms like fever and cough.
Discussion:
- This preliminary study investigated the expression and distribution of TRPC6 protein in normal and SARS-CoV-2 infected human lung tissues using immunohistochemistry.
- TRPC6 protein was detected in the ciliated epithelium, lung vasculature, and alveolar septa of normal lungs.
- In COVID-19 pneumonia lungs, TRPC6 showed altered distribution, with intensive labeling in inflammatory lesions, cellular infiltrates, hyaline membranes, fibrosis, and dilated capillaries.
Key Insights:
- TRPC6 protein expression is confirmed in human lung tissue.
- The distribution of TRPC6 is significantly altered in lungs affected by COVID-19 pneumonia.
- These findings support the involvement of TRPC6 in lung physiology and COVID-19 pathogenesis.
Outlook:
- TRPC6 may exacerbate SARS-CoV-2-induced inflammation.
- TRPC6 emerges as a potential therapeutic target for novel anti-inflammatory drugs in COVID-19 treatment.
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