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Updated: Sep 22, 2025
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Squamous cell carcinoma of verrucous type in the setting of prior pyoderma gangrenosum: a case report
Amy Morrison1, Carlene Waters-Hollingsworth2, G Mabel Gamboa2
1University of Central Florida College of Medicine, Orlando, USA. amy.morrison@knights.ucf.edu.
Introduction:
Pyoderma gangrenosum and cutaneous squamous cell carcinoma are two conditions well reported in the literature and may exist concurrently in the same patient. In fact, there have been reports of misdiagnosis of one for the other. The two conditions occurring in the same location, however, has not yet been reported.
Case Description:
We report the case of a 57-year-old Caucasian male with history of pyoderma gangrenosum of the right lateral tibial area who developed squamous cell carcinoma of verrucous type at the same site. Excisional surgery was considered to treat this patient, but he was ultimately managed with radiation therapy to the affected area due to the size of the lesion and the risk of triggering proliferation of the pyoderma gangrenosum.
Conclusions:
We hope that this case report will add to the literature of both conditions, show a unique presentation of both conditions, and emphasize the inclusion of both pyoderma gangrenosum and squamous cell carcinoma when developing a differential diagnosis of a chronic, nonhealing wound.
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