Related Experiment Video
Updated: Sep 22, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
The Intergenerational Impact of Structural Racism and Cumulative Trauma on Depression
Sidney H Hankerson1, Nathalie Moise1, Diane Wilson1
1Department of Psychiatry (Hankerson, Yehuda) and Department of Population Health Sciences and Policy (Hankerson), Icahn School of Medicine at Mount Sinai, New York; Department of Medicine (Moise, Wilson) and Department of Psychiatry (Waller, Duarte, Lugo-Candelas, Wainberg), Columbia University Irving Medical Center, New York; City University of New York (Wilson); New York State Psychiatric Institute, New York (Waller, Duarte, Lugo-Candelas, Wainberg, Weissman); Department of Family Medicine and Community Health, Perelman School of Medicine and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia (Arnold); Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York (Weissman); James J. Peters VA Medical Center, Bronx, N.Y. (Yehuda); Department of Psychiatry, University of California, Davis (Shim).
Abstract:
Depression among individuals who have been racially and ethnically minoritized in the United States can be vastly different from that of non-Hispanic White Americans. For example, African American adults who have depression rate their symptoms as more severe, have a longer course of illness, and experience more depression-associated disability. The purpose of this review was to conceptualize how structural racism and cumulative trauma can be fundamental drivers of the intergenerational transmission of depression. The authors propose that understanding risk factors for depression, particularly its intergenerational reach, requires accounting for structural racism. In light of the profoundly different experiences of African Americans who experience depression (i.e., a more persistent course of illness and greater disability), it is critical to examine whether an emerging explanation for some of these differences is the intergenerational transmission of this disorder due to structural racism.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Depression: Overview
Impact of Social Context on Individuals
Sources of Self-Esteem III: Social Comparison

