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Updates on Selective Brain Hypothermia: Studies From Bench Work to Clinical Trials
Xiaoyu Wang1,2, Alexandra Wehbe3, Shawn Kaura4
1Department of Luhe Institute of Neuroscience, Capital Medical University, Beijing, China.
Frontiers in Neurology
|May 23, 2022
Summary
Selective therapeutic hypothermia shows promise as a safe and effective adjuvant treatment for acute ischemic stroke (AIS), reducing infarct size and offering neuroprotection with fewer side effects than systemic approaches.
Area of Science:
- Neuroscience
- Cardiovascular Medicine
- Emergency Medicine
Background:
- Acute ischemic stroke (AIS) remains a leading cause of death and disability globally.
- Current treatments like thrombectomy and thrombolysis have limitations including time constraints and contraindications.
- Selective therapeutic hypothermia is emerging as a potential adjuvant therapy for AIS.
Purpose of the Study:
- To review current research on selective therapeutic hypothermia for AIS.
- To summarize findings from preclinical and clinical studies.
- To discuss the future prospects of selective hypothermia in neuroprotection.
Main Methods:
- Review of major preclinical studies in rodents and large animals.
- Analysis of clinical trials investigating selective hypothermia in AIS patients.
- Synthesis of data on efficacy, safety, and feasibility.
Main Results:
- Selective therapeutic hypothermia significantly reduces infarct volumes.
- It demonstrates neuroprotective effects in AIS models.
- The therapy minimizes systemic side effects compared to systemic hypothermia.
- Preclinical and clinical data confirm its safety and feasibility.
Conclusions:
- Selective therapeutic hypothermia is a safe and feasible adjuvant therapy for AIS.
- It offers neuroprotection and reduces infarct size with a favorable side effect profile.
- Further research into selective hypothermia and other neuroprotective strategies is warranted.
