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A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder
Veni Bharti1,2, Aseem Bhardwaj2, David A Elias3,4
1Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Frontiers in Psychiatry
|May 23, 2022
Summary
Individuals with post-traumatic stress disorder (PTSD) exhibit altered lipid profiles, with higher total cholesterol, LDL, and triglycerides, and lower HDL. These lipid dysregulations in PTSD may indicate risk and inform cardiovascular health strategies.
Area of Science:
- Cardiovascular Health
- Neuroscience
- Metabolic Disorders
Background:
- Mixed results exist regarding lipid profiles in post-traumatic stress disorder (PTSD).
- This meta-analysis aimed to clarify the relationship between lipid levels and PTSD.
Approach:
- A comprehensive meta-analysis was conducted using data from multiple databases (Embase, Medline, Scopus, PsycINFO, Cochrane) up to March 2021.
- Random-effects models synthesized findings from 17 studies involving 8,657 participants.
Key Points:
- PTSD patients showed significantly higher total cholesterol (TC), low-density lipoprotein (LDL), and triglyceride (TG) levels.
- High-density lipoprotein (HDL) levels were significantly lower in individuals with PTSD.
- Elevated TG levels in PTSD were consistent across various age groups, medication statuses, and BMI categories.
Conclusions:
- Dysregulation of lipid profiles is associated with PTSD, suggesting potential utility as a predictive biomarker.
- Understanding these lipid alterations can guide clinical practice to mitigate cardiovascular risks in PTSD patients.
Keywords:
fatty acidslipidsmajor depressive disorderpost-traumatic stress disorderpsychiatric disordersMore Related Videos
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