Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

217
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
217
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

692
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
692
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

270
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
270
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

147
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
147
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

324
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
324
Panic Disorder01:27

Panic Disorder

185
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
185

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the neurochemical basis of structure-function coupling in bipolar disorder: A multimodal data fusion analysis.

Journal of affective disorders·2026
Same author

Distance-related functional connectivity alterations in first-episode, drug-naïve major depressive disorder: a resting-state fMRI study with atlas-based neurotransmitter correlates.

BMC psychiatry·2026
Same author

Changes in neurovascular coupling of cerebral blood flow and functional connectivity strength in first-episode schizophrenia patients after antipsychotic treatment.

Schizophrenia research·2026
Same author

Linking macro-scale structural-functional networks to micro-scale neurotransmitter architectures in first-episode, drug-naïve OCD.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Neurovascular Coupling Disruption and Glymphatic Dysfunction Are Associated With Visual Impairment in Pediatric Monocular Anisometropic Amblyopia.

Investigative ophthalmology & visual science·2026
Same author

Glymphatic Dysfunction Coupled with Altered Neural Activity in High Myopia: Multimodal Study of Brain-Eye Interactions.

Annals of the New York Academy of Sciences·2026

Related Experiment Video

Updated: Sep 22, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.6K

Accelerated Brain Aging in Patients With Obsessive-Compulsive Disorder.

Liang Liu1, Junhong Liu1, Li Yang2

  • 1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Psychiatry
|May 23, 2022
PubMed
Summary

Obsessive-compulsive disorder (OCD) is linked to accelerated brain aging, indicated by higher brain-predicted age difference (brain-PAD) scores in patients compared to healthy controls. This suggests progressive structural brain changes in OCD pathogenesis.

Keywords:
brain agegray matter volume (GMV)machine learningobsessive-compulsive disorderstructural brain imaging

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

362
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

28.9K

Related Experiment Videos

Last Updated: Sep 22, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.6K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

362
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

28.9K

Area of Science:

  • Neuroscience
  • Radiology
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) may involve accelerated brain aging, but this remains unproven.
  • Understanding the structural brain changes associated with OCD is crucial for its pathogenesis.

Purpose of the Study:

  • To investigate whether patients with OCD exhibit accelerated brain aging compared to healthy controls (HCs).
  • To explore the relationship between brain aging and illness duration in OCD.

Main Methods:

  • A brain age prediction model was developed using mean gray matter volumes from T1-weighted MRI scans.
  • Voxel-based morphometry was used to obtain gray matter volumes.
  • The model was validated on two Chinese Han datasets and applied to patients with OCD to calculate brain-predicted age difference (brain-PAD) scores.

Main Results:

  • The brain age prediction model demonstrated consistent performance across datasets.
  • Patients with OCD showed significantly higher brain-PAD scores than matched HCs, indicating accelerated brain aging.
  • Brain-PAD scores were negatively correlated with the duration of illness, suggesting progressive changes.

Conclusions:

  • This study provides the first evidence of accelerated brain aging in patients with OCD.
  • The findings suggest that brain aging trajectories may be altered in OCD.
  • Brain-PAD scores may serve as a potential biomarker for progressive structural brain changes in OCD.