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Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy
Mingyue Wu1, Zixia Huang1, Lijin Zeng2
1Department of Anesthesiology, The Second Affiliated Hospital, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.
Insights
Cardiovascular diseases cause significant mortality. This review summarizes endothelial cell death mechanisms in myocardial infarction, suggesting inhibition as a potential therapeutic strategy.
Area of Science:
- Cardiovascular biology
- Cell death mechanisms
- Endothelial cell biology
Background:
- Cardiovascular disease, including coronary artery disease and stroke, is a leading global cause of death.
- Myocardial infarction (MI), a key manifestation of coronary heart disease, presents a major worldwide health challenge.
- Endothelial cells are critical for angiogenesis and myocardial repair, influencing MI prognosis.
Purpose of the Study:
- To review the different types of programmed cell death observed in endothelial cells during myocardial infarction.
- To elucidate the roles and underlying mechanisms of endothelial cell death in the context of MI.
- To explore the therapeutic potential of inhibiting endothelial cell death for treating myocardial infarction.
Main Methods:
- Literature review of programmed cell death pathways (apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy).
- Analysis of the involvement of these pathways in endothelial cells during myocardial infarction.
- Synthesis of current understanding of endothelial cell death in cardiovascular diseases.
Main Results:
- Various programmed cell death pathways are implicated in cardiovascular diseases like MI, heart failure, and myocarditis.
- Endothelial cell death plays a significant role in the pathophysiology of myocardial infarction.
- Understanding these mechanisms offers new insights into disease progression.
Conclusions:
- Endothelial cell death is a critical factor in myocardial infarction.
- Inhibiting specific endothelial cell death pathways presents a promising therapeutic avenue for MI.
- Targeting endothelial cell death could significantly improve treatment strategies and patient outcomes for cardiovascular diseases.
Abstract:
Cardiovascular disease, especially coronary artery disease and stroke, kills around one-third of the world's population, and myocardial infarction, a primary symptom of coronary heart disease, is a major worldwide health problem. Cardiovascular disease research has historically focused on promoting angiogenesis following myocardial damage. Myocardial vascular repair is crucial for improving myocardial infarction prognosis. Endothelial cells, the largest population of nonmyocytes within myocardial tissue, play an important role in angiogenesis. In recent years, different types of programmed cell death such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy have been described and found to be linked with cardiovascular diseases such as myocardial infarction, heart failure, and myocarditis. This will have important implications for reforming the treatment strategy of cardiovascular diseases. Different types of cell death of endothelial cells in myocardial infarction have been proposed, the roles and mechanisms of endothelial cell death in myocardial infarction are summarized in this review, and endothelial cell death inhibition as a therapeutic technique for treating myocardial infarction might be advantageous to human health.
