Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Endocrine System01:29

The Endocrine System

763
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
763
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.3K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

2.0K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.0K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.9K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

832
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
832
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

263
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
263

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.

Nature cell biology·2026
Same author

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.

Communications biology·2026
Same author

PFKM governs metabolic shifts throughout skeletal muscle differentiation.

Nature metabolism·2026
Same author

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.

bioRxiv : the preprint server for biology·2025
Same author

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins.

Nature chemical biology·2024
Same author

Sclerostin and Wnt Signaling in Idiopathic Juvenile Osteoporosis Using High-Resolution Confocal Microscopy for Three-Dimensional Analyses.

Children (Basel, Switzerland)·2024

Related Experiment Video

Updated: Sep 22, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

994

Metabolism and Endocrine Disorders: What Wnt Wrong?

Carolina N Franco1, May M Noe1, Lauren V Albrecht1,2

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of California Irvine, Irvine, CA, United States.

Frontiers in Endocrinology
|May 23, 2022
PubMed
Summary

This study explores the link between Wnt signaling and cell metabolism. Understanding this connection is key for tissue renewal and treating diseases like cancer.

Keywords:
SAMarginine methylationlysosomesmetabolomicsmethioninesclerostin

More Related Videos

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.4K
Methods to Test Endocrine Disruption in Drosophila melanogaster
09:43

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

9.9K

Related Experiment Videos

Last Updated: Sep 22, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

994
Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.4K
Methods to Test Endocrine Disruption in Drosophila melanogaster
09:43

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

9.9K

Area of Science:

  • Cell Biology
  • Metabolism
  • Biomedical Research

Background:

  • Wnt signaling is crucial for tissue growth, remodeling, and organ formation.
  • Dysregulated Wnt signaling is implicated in various human diseases, notably cancer.
  • The intersection of Wnt signaling with metabolic networks remains poorly understood.

Purpose of the Study:

  • To investigate how Wnt signaling influences metabolic networks for tissue growth and remodeling.
  • To leverage advanced technologies for visualizing and manipulating cellular metabolism.
  • To address fundamental questions in cell biology regarding nutrient regeneration and tissue maintenance.

Main Methods:

  • Utilizing cutting-edge chemical biology techniques.
  • Employing metabolomics for comprehensive metabolic profiling.
  • Applying live microscopy for real-time observation of cellular processes.
  • Integrating these tools within innovative model systems.

Main Results:

  • Technological advancements have enabled unprecedented visualization and manipulation of metabolism in living cells and tissues.
  • The Wnt signaling field is advancing rapidly by integrating metabolic insights.
  • New understanding is emerging regarding cell metabolism in both health and disease states.

Conclusions:

  • Elucidating Wnt signaling and metabolism in a cell-type and tissue-specific manner is critical.
  • This knowledge will benefit basic science and clinical research.
  • Findings hold promise for developing novel therapies for diseases and aging.