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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Cisapride versus Maren Pill for Functional Constipation: A Meta-Analysis.

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Cisapride demonstrates superior efficacy and safety for functional constipation (FC) compared to Maren pill. This meta-analysis confirms cisapride as a better treatment option, with lower recurrence and adverse event rates.

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Clinical Medicine

Background:

  • Functional constipation (FC) poses a significant clinical challenge, with limited understanding of optimal therapeutic strategies.
  • The comparative efficacy and safety of cisapride and Maren pill for FC require elucidation.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the efficacy and safety of cisapride versus Maren pill in treating functional constipation.
  • To compare therapeutic effectiveness, recurrence rates, and adverse event incidence between the two treatments.

Main Methods:

  • A systematic search of multiple databases (PubMed, Web of Science, Embase, etc.) was performed for comparative studies up to December 2021.
  • Five studies involving 414 patients with FC were included in the quantitative meta-analysis.
  • Primary outcome: therapeutic effectiveness rate. Secondary outcomes: recurrence rate and adverse event incidence.

Main Results:

  • Cisapride exhibited a significantly higher therapeutic effectiveness rate (90.78%) compared to Maren pill (64.97%) (P < 0.05).
  • The incidence of adverse events was lower in the cisapride group (10.08%) than in the Maren pill group (13.95%) (P < 0.05).
  • Recurrence rates were also significantly lower with cisapride (32.31%) versus Maren pill (53.16%) (P < 0.05).

Conclusions:

  • Cisapride is a more effective treatment for functional constipation than Maren pill, associated with reduced recurrence and adverse event rates.
  • Cisapride represents a superior therapeutic option for managing functional constipation.
  • Future research could explore combination therapy with cisapride and Maren pill to potentially enhance efficacy and reduce cisapride dosage.