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3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration
Suhun Chae1,2, Uijung Yong3, Wonbin Park1
1Department of Mechanical Engineering, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Gyeongsangbuk-do, Pohang, 37673, South Korea.
Bioactive Materials
|May 23, 2022
Summary
This study developed a 3D-printed gradient construct to regenerate rotator cuff (RC) tendon-bone interfaces (TBI). The biomimetic implant successfully promoted functional RC healing and restored shoulder movement in a rat model.
Area of Science:
- Biomaterials Engineering
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Rotator cuff (RC) injuries are prevalent, with challenging tendon-bone interface (TBI) healing after repair.
- Current treatments often yield suboptimal outcomes, necessitating advanced regenerative strategies.
Purpose of the Study:
- To engineer a biomimetic, gradient cell-laden multi-tissue construct for complex TBI reconstruction.
- To evaluate the 3D cell-printed construct's efficacy in promoting functional RC regeneration and TBI healing.
Main Methods:
- Utilized 3D cell-printing technology to create gradient scaffolds with TBI-specific bioinks.
- Conducted in vitro studies to assess zone-specific inducibility and multi-tissue formation.
- Evaluated in vivo regenerative performance in a rat RC repair model using near-infrared fluorescence imaging.
Main Results:
- The gradient scaffold system demonstrated zone-specific inducibility and mimicked TBI in vitro.
- 3D cell-printed implants effectively restored shoulder locomotion function in vivo.
- The constructs accelerated TBI healing and demonstrated functional RC regeneration.
Conclusions:
- 3D cell-printed gradient constructs offer therapeutic potential for functional rotator cuff regeneration.
- This biomimetic approach shows translational promise for clinical repair of multi-tissue interfaces.
