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Updated: Sep 22, 2025

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation
Published on: October 15, 2019
Coordinated motion of molecular motors on DNA chains with branch topology
1Department of Engineering Mechanics, Zhejiang University, Hangzhou, 310058 China.
Abstract:
To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsKC on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsKC motors on DNA chains with varied branch topologies. Our studies indicate that multiple FtsKC motors can have coordinated motion, which is mainly due to the force-responsive behavior of individual FtsKC motors. We further suggest the potential application of motors of FtsKC, together with DNA chains of specific branch topology, to serve as strain sensors in hydrogels.
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