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Related Experiment Video

Updated: Sep 22, 2025

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
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Dynamic Relationship Between Interhemispheric Functional Connectivity and Corticospinal Tract Changing Pattern After

Jingchun Liu1, Caihong Wang2, Jingliang Cheng2

  • 1Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.

Frontiers in Aging Neuroscience
|May 23, 2022
PubMed
Summary
This summary is machine-generated.

Acute fractional anisotropy (FA) of the primary motor cortex (M1) fiber is a key predictor of long-term motor recovery after subcortical stroke. Increased M1-M1 resting-state functional connectivity (rsFC) may compensate for corticospinal tract (CST) damage.

Keywords:
cerebral infarctioncorticospinal tractdiffusion tensor imagingfunctional neuroimagingmotorneuronal plasticity

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Subcortical stroke impairs corticospinal tract (CST) function, impacting motor recovery.
  • Interhemispheric resting-state functional connectivity (rsFC) between primary motor cortices (M1) may compensate for CST damage.

Purpose of the Study:

  • Investigate longitudinal changes in M1-M1 rsFC and CST diffusion indices post-stroke.
  • Examine correlations between M1-M1 rsFC, CST integrity, and long-term motor outcomes.

Main Methods:

  • Longitudinal MRI (dMRI, rs-fMRI) and clinical assessments in 44 subcortical stroke patients.
  • Diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) of affected CSTs.
  • Linear mixed-effects modeling to analyze longitudinal changes and relationships.

Main Results:

  • Decreased FA in affected CSTs and increasing M1-M1 rsFC observed from acute to chronic stages.
  • Negative correlation between M1 M1 fiber FA and M1-M1 rsFC (subacute to chronic).
  • Acute M1 fiber FA significantly correlated with long-term motor recovery.

Conclusions:

  • Acute M1 fiber FA is a potential imaging biomarker for predicting motor recovery after stroke.
  • Compensatory M1-M1 rsFC enhancement may initiate in the subacute stage following CST impairment.