Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Authors Reply: Ventilator Liberation after Pediatric Cardiac Surgery: Balancing the Competing Interests of the Lungs and the Heart.

Respiratory care·2026
Same author

Anticoagulation management and monitoring in ECMO: an international survey: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis.

Research and practice in thrombosis and haemostasis·2026
Same author

Postextubation Arterial Blood Gas to Predict Reintubation in Children With Congenital Heart Disease.

Respiratory care·2026
Same author

Comparing Rotational Thromboelastometry and Standard Coagulation Assays for Predicting Intraoperative Bleeding in Pediatric Liver Transplantation.

Pediatric transplantation·2026
Same author

Factor XIII Concentrate Mitigates Hemorrhage in Pediatric Extracorporeal Membrane Oxygenation Support With Acquired Factor XIII Deficiency.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2025
Same author

Hyperoxia During Neonatal Cardiopulmonary Bypass Is Associated With Worse Clinical Outcomes: A Multi-Institutional Study.

Journal of the American Heart Association·2025

Related Experiment Video

Updated: Sep 22, 2025

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

13.9K

Viscoelastic Testing in Pediatric Mechanical Circulatory Support.

Katherine Regling1, Arun Saini2, Katherine Cashen3

  • 1Division of Hematology Oncology, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University School of Medicine, Detroit, MI, United States.

Frontiers in Medicine
|May 23, 2022
PubMed
Summary
This summary is machine-generated.

Viscoelastic testing (VET) aids anticoagulation management in pediatric mechanical circulatory support. This review explores TEG®/ROTEM® utility for extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (VAD).

Keywords:
child-ageextracorporeal membrane oxygenationpediatricthromboelastographythromboelastometry (ROTEM®)ventricular assist device (VAD)

More Related Videos

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research
07:53

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Published on: April 26, 2024

683
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

796

Related Experiment Videos

Last Updated: Sep 22, 2025

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

13.9K
Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research
07:53

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Published on: April 26, 2024

683
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

796

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Biomedical engineering

Background:

  • Mechanical circulatory support (MCS) is vital for critically ill children.
  • Anticoagulation management in pediatric MCS is complex due to unique physiological factors.
  • Viscoelastic testing (VET) offers a global assessment of hemostasis.

Purpose of the Study:

  • To review the application of TEG®/ROTEM® in pediatric patients on ECMO and VAD.
  • To discuss laboratory and patient-specific considerations for VET interpretation.
  • To evaluate VET's association with clinical outcomes.

Main Methods:

  • Systematic review of adult and pediatric literature on VET in MCS.
  • Analysis of TEG®/ROTEM® values and platelet mapping data.
  • Comparison of VET with standard laboratory monitoring.

Main Results:

  • VET provides a comprehensive hemostatic profile, including clot initiation, strength, and lysis.
  • Platelet mapping via VET can guide targeted therapy.
  • VET may offer advantages over standard tests in guiding blood product use and predicting outcomes.

Conclusions:

  • VET, particularly TEG®/ROTEM®, is a valuable tool for managing anticoagulation in pediatric MCS.
  • Further research is needed to standardize VET protocols and confirm its impact on patient outcomes.
  • Integration of VET into clinical practice can optimize patient care and resource utilization.