Related Experiment Video
Updated: Sep 22, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer
Fanhua Kang1, Feng Jiang2, Lingzi Ouyang1
1Department of Pathology, Xiangya Changde Hospital, Changde, China.
Abstract:
Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and treatment of gastrointestinal cancer. It has been confirmed that long non-coding RNAs (lncRNAs) exert a range of biological functions, such as cell metastasis, tumorigenesis, and therapeutic responses. This review mainly focused on the emerging roles and underlying molecular mechanisms of exosome-derived lncRNAs in gastrointestinal cancer in recent years. The biological roles of exosomal lncRNAs in the pathogenesis and therapeutic responses of gastrointestinal cancers were also investigated.
More Related Videos
Related Concept Videos
lncRNA - Long Non-coding RNAs
Non-LTR Retrotransposons
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
MicroRNAs
RNA Splicing

