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A severe oxaliplatin immune-induced syndrome after oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy
Anne-Cecile Ezanno1, Brice Malgras1, Olivier Aoun2
1Department of Gastrointestinal and Endocrine Surgery, Bégin Military Hospital, St Mandé, France.
Objectives:
Oxaliplatin immune-induced syndrome (OIIS) was recently recognized as an uncommon complication of oxaliplatin therapy.
Methods:
We report an exceptionally OIIS after pressurized intraperitoneal aerosol chemotherapy (PIPAC).
Results:
Our patient developed a severe OIIS probably related to the intraperitoneal administration of oxaliplatin. Specific tests were performed and detected high-titer antibodies to oxaliplatin.
Conclusions:
The OIIS is a rare. Physicians had to be aware of that clinical situation because it could be reversible, even in case of peritoneal advanced disease, and ICU treatment is justified.
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