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Updated: Sep 22, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Microbiota in Tumors: From Understanding to Application.

Yifan Xie^1,2, Feng Xie³, Xiaoxue Zhou²

¹School of Medicine, Zhejiang University City College, Suzhou, 215123, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|May 23, 2022

Summary

Intratumor microbiota, microbes within tumors, influences cancer progression through various mechanisms. Understanding their sources, functions, and heterogeneity is crucial for developing novel antitumor treatments.

Keywords:

anti-tumor therapy intratumor microbiota microbial community heterogeneity omics technology source of microbes tumorigenesis

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

Area of Science:

Oncology
Microbiology
Cancer Research

Background:

Intratumor microbiota, microbes residing within tumors, are increasingly recognized as key players in the tumor microenvironment.
Despite their significance, intratumor microbiota remain poorly understood due to challenges like low biomass and complex interactions.
Sources of intratumor microbiota include mucosal sites, adjacent normal tissues, and hematogenous spread.

Purpose of the Study:

To review recent advancements in understanding intratumor microbiota.
To explore the sources, functions, mechanisms, and heterogeneity of intratumor microbiota.
To discuss techniques for studying intratumor microbiota and their implications for antitumor therapies.

Main Methods:

Review of existing literature on intratumor microbiota.
Analysis of omics techniques (e.g., metagenomics, metatranscriptomics) for microbial profiling.
Integration of immunological methods to assess host-microbe interactions.

Main Results:

Intratumor microbiota influence tumor progression via DNA damage, oncogenic pathway activation, immunosuppression, and drug metabolism.
Significant heterogeneity exists in the composition and abundance of intratumor microbiota across different tumor types.
Microbiota play diverse roles in tumor progression, necessitating type-specific investigations.

Conclusions:

Intratumor microbiota represent a promising target for cancer therapy.
Further research into microbiota-tumor interactions can guide the development of innovative treatment strategies.
Technological advancements are enhancing our ability to study and manipulate intratumor microbiota for therapeutic benefit.