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Updated: Sep 22, 2025
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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Engineering fungal terpene biosynthesis
Zhiyong Yin1, Jeroen S Dickschat1
1Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany. dickschat@uni-bonn.de.
Natural Product Reports
|May 23, 2022
Summary
This review covers fungal terpenoids from 2015-2022, focusing on discovering new biosynthetic genes and pathways. It also details using known genes to create high-yielding fungal production strains.
Area of Science:
- Biochemistry
- Molecular Biology
- Mycology
Background:
- Fungal terpenoids possess significant structural diversity and biological activities.
- Research has increasingly focused on fungal terpenoid biosynthesis and production.
Purpose of the Study:
- To review recent advancements (2015-2022) in fungal terpenoid research.
- To summarize the discovery of novel biosynthetic genes and pathways.
- To highlight the engineering of production strains using known biosynthetic genes.
Main Methods:
- Literature review of scientific publications from 2015 to 2022.
- Analysis of studies on fungal terpenoid biosynthesis.
- Examination of metabolic engineering strategies for fungal production.
Main Results:
- Identification of diverse fungal terpenoid structures and their associated biological activities.
- Elucidation of previously unknown genes and pathways involved in fungal terpenoid synthesis.
- Development of strategies for enhancing fungal terpenoid yields through genetic engineering.
Conclusions:
- Significant progress has been made in understanding fungal terpenoid biosynthesis.
- Metabolic engineering holds promise for the efficient production of valuable fungal terpenoids.
- Continued research is crucial for unlocking the full potential of fungal terpenoids.
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