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Related Experiment Videos

[Local irritation study with isepamicin].

T Kohira, J Yano, Y Kobayashi

    The Japanese Journal of Antibiotics
    |December 1, 1986
    PubMed
    Summary

    Isepamicin (HAPA-B) demonstrated minimal muscle and vascular irritation in rabbits, comparable to amikacin (AMK) and less than acetic acid, indicating a favorable local tolerance profile.

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    The Journal of pharmacology and experimental therapeutics·1992

    Area of Science:

    • Pharmacology
    • Toxicology
    • Preclinical Research

    Context:

    • Aminoglycoside antibiotics are crucial in treating bacterial infections.
    • Assessing local tissue irritation is vital for drug safety and administration routes.
    • Japanese White rabbits are a standard model for local tolerance studies.

    Purpose:

    • To evaluate the local irritative effects of isepamicin (HAPA-B) on muscle and blood vessels.
    • To compare the irritogenicity of isepamicin with amikacin (AMK) and acetic acid.
    • To determine the safety profile of isepamicin for parenteral administration.

    Summary:

    • Muscle irritation experiments involved injecting isepamicin (HAPA-B), amikacin (AMK), saline, or acetic acid into rabbit musculus sacrospinalis.
    • Vascular irritation was assessed by prolonged contact of isepamicin (HAPA-B) with the rabbit vena retroauricularis.
    • Isepamicin (HAPA-B) exhibited mild muscular irritation, less than 0.75% acetic acid but more than saline, and similar to amikacin (AMK).
    • Vascular irritation from isepamicin (HAPA-B) was minimal, causing slight inflammation without thrombus formation.

    Impact:

    • Results suggest isepamicin (HAPA-B) has a low potential for local tissue damage upon administration.
    • The findings support the safety of isepamicin (HAPA-B) for intramuscular or intravenous use.
    • This study provides essential data for the clinical development and application of isepamicin.

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