Promising antimicrobials from Phoma spp.: progress and prospects

Area of Science:

• Microbiology
• Mycology
• Natural Product Chemistry

Background:

• Rising multidrug-resistance in pathogens and emerging diseases like coronaviruses demand novel antimicrobials.
• The discovery of penicillin initiated research into fungal antimicrobial capabilities, with a focus on Phoma species.
• Phoma species are known producers of diverse bioactive metabolites with demonstrated antimicrobial activity.

Purpose of the Study:

• To review the antimicrobial potential of secondary metabolites from various Phoma species.
• To discuss the biogenic synthesis of silver nanoparticles from Phoma and their antimicrobial applications.

Main Methods:

• Literature review of studies on Phoma species and their metabolites.
• Analysis of reported antimicrobial activities (antibacterial, antifungal, antiviral).
• Examination of research on silver nanoparticle synthesis using Phoma extracts.

Main Results:

• Phoma species produce a range of bioactive compounds like polyketides, terpenoids, and alkaloids.
• These metabolites exhibit significant antibacterial, antifungal, and antiviral activities against various pathogens.
• Phoma-derived silver nanoparticles show potential as effective antimicrobial agents.

Conclusions:

• Secondary metabolites from Phoma species represent a valuable source for developing new antimicrobial drugs.
• Eco-friendly synthesis of silver nanoparticles using Phoma offers a novel approach to combating microbial infections.
• Further research into Phoma-derived compounds and nanoparticles is crucial for addressing antimicrobial resistance.