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Related Experiment Video

Updated: Sep 22, 2025

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

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Circuit-Targeted Neuromodulation for Anhedonia.

Shan H Siddiqi1,2, Nichola Haddad3,4, Michael D Fox3,4,5

  • 1Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. shsiddiqi@bwh.harvard.edu.

Current Topics in Behavioral Neurosciences
|May 23, 2022
PubMed
Summary

Anhedonia, the inability to feel pleasure, is common in psychiatric disorders. This review explores brain circuit-targeted treatments, including brain stimulation and neuromodulation, for anhedonia.

Keywords:
CircuitDBSDeep brain stimulationNetworkNeuromodulationTMSTranscranial magnetic stimulation

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Last Updated: Sep 22, 2025

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuromodulation

Background:

  • Anhedonia is a core symptom in various psychiatric disorders, impacting treatment selection and prognosis.
  • Current pharmacological and psychosocial treatments for anhedonia present significant challenges.
  • There is growing interest in neuroanatomically-targeted therapies for anhedonia.

Purpose of the Study:

  • To provide an overview of circuit-targeted therapeutics in psychiatry.
  • To review brain mapping techniques relevant to anhedonia.
  • To summarize existing brain stimulation studies for anhedonia.
  • To describe novel neuromodulation approaches for anhedonia.

Main Methods:

  • Review of literature on circuit-targeted therapeutics.
  • Examination of brain mapping studies related to anhedonia.
  • Analysis of existing research on brain stimulation interventions.
  • Description of emerging neuromodulation techniques.

Main Results:

  • The chapter outlines the foundational concepts of circuit-targeted treatments.
  • It details the application of brain mapping in understanding anhedonia.
  • Existing brain stimulation studies for anhedonia are reviewed.
  • Emerging neuromodulation strategies are presented.

Conclusions:

  • Circuit-based neuromodulation offers promising avenues for treating anhedonia.
  • Understanding brain circuits is crucial for developing effective anhedonia therapies.
  • Further research into targeted neuromodulation is warranted.