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Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
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Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia
Kyung Euy Hong1, Seong Ah Kim1, Da-Young Shin2
1Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Investigative Ophthalmology & Visual Science
|May 23, 2022
Summary
Myopia-related structural and vascular changes in glaucoma patients impact central vision. Lower deep vessel density and increased peripapillary fluctuation are linked to central vision loss in myopia with glaucoma.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Myopia Studies
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Myopia is a common comorbidity in glaucoma patients.
- Central visual function is critical for daily activities.
Purpose of the Study:
- To investigate ocular and hemodynamic factors influencing central visual function in glaucoma patients with myopia.
- To analyze the association between structural and vascular parameters and central visual field defects.
Main Methods:
- Prospective observational study of 236 eyes from 140 normal-tension glaucoma patients with varying myopia.
- Assessment of ocular characteristics (axial length, PPA, disc parameters) and hemodynamic factors (HRV, OCTA-derived vessel density).
- Multivariate logistic regression to analyze associations with central visual field sensitivity and scotoma.
Main Results:
- Deep layer vessel density differed significantly between mild and moderate-to-severe myopia.
- Peripapillary atrophy correlated with peripapillary vessel density.
- Lower heart rate variability (SDNN), lower macular deep vessel density, and greater peripapillary vessel density fluctuation were associated with central scotoma.
Conclusions:
- Myopia-induced structural changes, particularly in the peripapillary region, affect retinal vessel density.
- Reduced deep vessel density and increased peripapillary vessel density fluctuation are linked to central scotoma in myopic glaucoma patients.
- Both structural and vascular alterations due to myopia may contribute to compromised central visual function in glaucoma.
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