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Updated: Sep 22, 2025

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
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Tick-borne encephalitis virus.

L Paul Phipps1, Nicholas Johnson1

  • 1Virology Department, The Animal and Plant Health Agency, New Haw, Addlestone, Surrey, KT153NB, UK.

Journal of Medical Microbiology
|May 23, 2022
PubMed
Summary
This summary is machine-generated.

Tick-borne encephalitis (TBE) is a growing threat caused by a virus spread by ticks. While often mild, severe neurological illness, lasting effects, or death can occur, but vaccination offers effective prevention.

Keywords:
ticktick-borne encephalitisvaccination

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Area of Science:

  • Virology
  • Epidemiology
  • Neurology

Background:

  • Tick-borne encephalitis (TBE) is caused by a neurotropic flavivirus transmitted by Ixodes ticks.
  • TBE incidence is increasing and its geographical range is expanding across Eurasia and the Far East.
  • While most infections are asymptomatic, 2-30% of cases can lead to severe neurological disease, sequelae, or death.

Purpose of the Study:

  • To summarize the key aspects of Tick-borne encephalitis (TBE).
  • To highlight the diagnostic criteria and management of TBE.
  • To emphasize the importance of vaccination for TBE prevention.

Main Methods:

  • Diagnosis relies on clinical presentation of neurological disease.
  • Serological confirmation involves detecting virus-specific IgM and IgG antibodies.
  • No specific antiviral treatment exists; management is supportive.

Main Results:

  • TBE virus infection can result in severe neurological complications.
  • Long-term neurological sequelae and mortality are potential outcomes.
  • Vaccination is a proven effective method for preventing TBE.

Conclusions:

  • TBE poses a significant and expanding public health risk.
  • Early diagnosis and supportive care are crucial for managing TBE.
  • Vaccination remains the most effective strategy for TBE prevention.