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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

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Published on: October 7, 2011

JMM Profile: Louping ill virus.

Arran J Folly¹, Lorraine M McElhinney², Nicholas Johnson¹

¹Vector-borne diseases, Virology Department, Animal and Plant Health Agency, Woodham Lane, Weybridge, KT15 3NB, UK.

Journal of Medical Microbiology

|May 23, 2022

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Louping ill virus (LIV) poses a significant threat to livestock and humans in Great Britain and Ireland. This tick-borne flavivirus can cause fatal encephalitis, impacting animal health and the rural economy.

Area of Science:

Veterinary Virology
Arthropod-borne Diseases
Public Health

Background:

Louping ill virus (LIV) is a tick-borne flavivirus affecting livestock in Great Britain and Ireland.
It causes febrile illness and potentially fatal encephalitis in animals.
LIV can also infect humans, posing a zoonotic risk.

Purpose of the Study:

To highlight the significance of Louping ill virus (LIV) as a threat to animal and human health.
To underscore the economic impact of LIV on rural communities.
To discuss the historical and current challenges in LIV prevention.

Main Methods:

Review of existing literature on Louping ill virus.
Analysis of disease transmission dynamics via tick vectors.

Keywords:

Flaviviridae Ixodes ricinus vector-borne disease zoonotic disease

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Examination of prevention strategies including acaricides, land management, and vaccination.

Main Results:

LIV is transmitted by infected ticks, primarily affecting livestock.
Disease progression can lead to severe encephalitis and mortality.
Vaccines, once a key prevention tool, have been discontinued.

Conclusions:

Louping ill virus remains a significant concern for veterinary and human health.
The discontinuation of vaccines necessitates re-evaluation of control strategies.
Integrated approaches are crucial for managing this tick-borne flavivirus.