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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammation01:38

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Overview
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Related Experiment Video

Updated: Sep 22, 2025

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
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A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

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Targeting inflammation with collagen.

Dennis Schwarz1, Marie Lipoldová2, Holger Reinecke1

  • 1Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.

Clinical and Translational Medicine
|May 23, 2022
PubMed
Summary

Collagen peptides may reduce inflammation in damaged tissues by improving the extracellular matrix (ECM). Further research is needed to fully understand this anti-inflammatory mechanism and potential side effects.

Keywords:
COVID-19ECMMMPscollageninflammation

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Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
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Production of Nanofibrillar Patterned Collagen for Tissue Engineering
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Area of Science:

  • Biomedical Science
  • Immunology
  • Extracellular Matrix Research

Background:

  • Tissue damage from infections or autoimmune diseases degrades extracellular matrix (ECM) collagen, exacerbating inflammation.
  • Modulating the ECM in inflamed tissues presents a potential therapeutic strategy.
  • Recent studies explored polymerised type I collagen (PTIC) for COVID-19, suggesting novel anti-inflammatory roles.

Purpose of the Study:

  • To explore potential mechanisms behind the anti-inflammatory effects of collagen peptides.
  • To review possible side effects associated with collagen deposition in inflammatory conditions.
  • To summarize current knowledge on collagen's role in mitigating residual risk in inflammatory diseases.

Main Methods:

  • Literature review and synthesis of existing research on collagen, ECM, and inflammation.
  • Analysis of studies investigating collagen's therapeutic potential, including in COVID-19.
  • Discussion of proposed mechanisms for collagen's anti-inflammatory action.

Main Results:

  • Collagen degradation in the ECM is linked to increased inflammation.
  • Collagen peptides may offer a therapeutic approach to reduce inflammation and improve ECM.
  • The precise mechanisms and potential adverse effects of collagen in inflammatory diseases require further investigation.

Conclusions:

  • Collagen peptides show promise in reducing inflammation and potentially mitigating residual risk in inflammatory diseases.
  • While promising, the anti-inflammatory mechanisms of collagen remain largely elusive.
  • Further research is essential to elucidate these mechanisms and confirm safety and efficacy.