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Updated: Sep 22, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Progressive Lacunar Strokes: A Predictive Score.

Saima Bashir¹, Mikel Terceño¹, Maria Buxó²

¹Stroke Unit. Department of Neurology. Hospital UniversitarI Doctor Josep Trueta de Girona. Girona Biomedical Research Institute (IDIBGI). Girona, Spain.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|May 23, 2022

Summary

A new predictive score helps identify patients with lacunar stroke at high risk for progressive lacunar syndromes (PLS). This tool aids in early intervention for patients prone to long-term dependency.

Keywords:

Lacunar syndrome Prognosis Progressive lacunar stroke Risk score

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Area of Science:

Neurology
Stroke Medicine
Clinical Prediction Models

Background:

Progressive lacunar syndromes (PLS) affect 20-30% of lacunar stroke patients.
PLS significantly increases the risk of long-term functional dependency.

Purpose of the Study:

To develop a predictive score for identifying patients at high risk of developing PLS.
To aid in early intervention for patients with lacunar stroke.

Main Methods:

A risk score was derived from a cohort of 187 patients with lacunar syndromes.
Logistic regression and receiver operating characteristic (ROC) analysis were used.
Predictive factors included diabetes, diastolic blood pressure, motor syndrome, and asymptomatic intracranial atheromatosis.

Main Results:

52 (27.8%) of patients presented with PLS.
Independent predictors for PLS were identified: diabetes, diastolic blood pressure, pure motor syndrome, and asymptomatic intracranial atheromatosis.
The predictive model achieved an area under the ROC curve of 0.77.

Conclusions:

The developed score can be a valuable tool in clinical practice.
It facilitates the identification of high-risk patients for PLS and potential long-term dependency.
Early identification allows for timely and intensive treatment strategies.