Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

55.5K
Overview
55.5K
Inflammatory Response01:28

Inflammatory Response

8.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
8.9K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

12.7K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
12.7K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

5.8K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
5.8K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.3K
Adherens Junctions01:24

Adherens Junctions

5.1K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adenine-DNA adducts derived from the highly tumorigenic Dibenzo[a,l]pyrene are resistant to nucleotide excision repair while guanine adducts are not.

Chemical research in toxicology·2013
Same author

Application of acoustic radiation force impulse imaging for the evaluation of focal liver lesion elasticity.

Hepatobiliary & pancreatic diseases international : HBPD INT·2013
Same author

KLF4 promoted odontoblastic differentiation of mouse dental papilla cells via regulation of DMP1.

Journal of cellular physiology·2013
Same author

Tertiary origin and pleistocene diversification of dragon blood tree (Dracaena cambodiana-Asparagaceae) populations in the Asian tropical forests.

PloS one·2013
Same author

Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer.

PloS one·2013
Same author

Myeloid differentiation factor 88 promotes growth and metastasis of human hepatocellular carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2013

Related Experiment Video

Updated: Sep 22, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.7K

Apelin/APJ system in inflammation.

Xu Wang1, Lu Zhang1, Peisen Li1

  • 1Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.

International Immunopharmacology
|May 23, 2022
PubMed
Summary

The apelin/APJ system, involving apelin and its receptor APJ, plays a crucial role in regulating inflammation. This system shows potential as a therapeutic target for various inflammation-exacerbated diseases.

Keywords:
Apelin/APJCytokinesGene regulationInflammationInflammation-related diseases

More Related Videos

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.4K
Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
06:43

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

10.0K

Related Experiment Videos

Last Updated: Sep 22, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.7K
A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.4K
Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
06:43

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

10.0K

Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • The apelin/APJ system, comprising apelin and its receptor APJ, is widely distributed in the central nervous system and various organs.
  • This system is increasingly recognized for its involvement in both physiological functions and pathophysiological conditions.

Purpose of the Study:

  • To review recent research on the apelin/APJ system, focusing on its influence on inflammation.
  • To analyze the mechanisms by which apelin regulates inflammation-related diseases.
  • To evaluate apelin and APJ as potential therapeutic targets for inflammatory diseases.

Main Methods:

  • Literature review of recent studies on the apelin/APJ system and inflammation.
  • Analysis of molecular pathways, including nuclear factor-κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2).
  • Examination of the apelin/APJ system's role in diverse diseases with inflammatory components.

Main Results:

  • Apelin/APJ signaling can inhibit inflammatory responses through mechanisms like NF-κB down-regulation and ERK1/2 up-regulation.
  • The apelin/APJ system is implicated in numerous diseases, including cardiovascular, liver, kidney, neurological, and inflammatory conditions.
  • Dysregulation of apelin levels can exacerbate disease states where inflammation is a key factor.

Conclusions:

  • The apelin/APJ system significantly influences inflammation and is involved in a wide range of diseases.
  • Apelin's regulatory role in inflammation provides a mechanistic basis for its involvement in disease pathogenesis.
  • Apelin and APJ represent promising therapeutic targets for treating diseases associated with or worsened by inflammation.