Bidirectional relations between depression symptoms and chronic kidney disease
Mengyi Liu1, Yanjun Zhang1, Sisi Yang1
1Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515, China.
Journal of Affective Disorders
|May 23, 2022
Summary
This study found that depression and chronic kidney disease (CKD) have a two-way relationship. Higher depressive symptoms increase CKD risk, and CKD increases depression risk in adults.
Area of Science:
- Nephrology
- Psychiatry
- Epidemiology
Background:
- Depression and chronic kidney disease (CKD) frequently co-occur.
- The bidirectional relationship between depression and CKD is not fully understood.
- This study investigates the link between renal function and depression in adults.
Purpose of the Study:
- To examine the bidirectional relationship between renal function and depression.
- To assess if depressive symptoms predict the development of CKD.
- To determine if CKD predicts the development of depression.
Main Methods:
- Utilized data from the Coronary Artery Risk Development in Young Adults study.
- Analysis 1: 3,731 participants without CKD assessed depressive symptoms and incident CKD.
- Analysis 2: 2,994 participants without depression assessed renal function and incident depression.
Main Results:
- Elevated depressive symptoms (CES-D scores ≥16) were associated with an increased risk of developing CKD.
- Chronic kidney disease (CKD) was significantly associated with a 36% increased risk of developing depression.
- Both associations were observed in a cohort of young and middle-aged adults over 20 years.
Conclusions:
- A bidirectional association between depression and CKD was identified.
- This prospective cohort study highlights the interconnectedness of mental and kidney health.
- Further research may explore underlying mechanisms and clinical implications.
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