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Cardiac repolarization abnormalities in children with familial Mediterranean fever

Yomna Farag1, Shaimaa Sayed2, Fatma Alzhraa Mostafa1

  • 1Pediatrics department, Faculty of Medicine, Cairo University, 4 extension of Nobar Street, Cairo, Egypt.

Pediatric Rheumatology Online Journal
|May 23, 2022
PubMed
Abstract

Insights

Children with Familial Mediterranean Fever (FMF) show increased cardiac repolarization abnormalities, indicating a higher risk for arrhythmia. Regular monitoring and better disease control are recommended for these patients.

Area of Science:

  • Cardiology
  • Pediatrics
  • Genetics

Background:

  • Familial Mediterranean Fever (FMF) is an autoinflammatory condition.
  • Cardiac involvement in FMF can manifest as conduction disturbances and arrhythmias.
  • Assessing cardiac repolarization abnormalities in children with FMF is crucial.

Purpose of the Study:

  • To evaluate the susceptibility of children with FMF to cardiac repolarization abnormalities.
  • To determine the risk of arrhythmia in pediatric FMF patients.
  • To investigate the relationship between FMF severity and cardiac electrical activity.

Main Methods:

  • A cross-sectional study involving 60 children with FMF and 40 healthy controls.
  • Electrocardiogram (ECG) and echocardiography were used to assess cardiac repolarization markers, dimensions, and functions.
  • Analysis included corrected QT (QTc) interval, Tpe/QTc ratio, and P wave dispersion (Pd).

Main Results:

  • FMF patients exhibited significantly increased QTc and Tpe/QTc ratios compared to controls.
  • P wave dispersion (Pd) was significantly higher in FMF patients with amyloidosis.
  • Pd correlated negatively with age and positively with disease severity; Tpe/QTc correlated with FMF score.

Conclusions:

  • Children with FMF have an increased risk of cardiac arrhythmia.
  • Regular cardiac monitoring is essential for pediatric FMF patients.
  • Improved disease control and colchicine compliance may reduce arrhythmia risk.
Keywords:
ArrhythmiasCardiac repolarizationFamilial Mediterranean fever

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