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Related Experiment Video

Updated: Sep 22, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Dynamic functional connectivity patterns associated with dementia risk.

Sophie Dautricourt1,2, Julie Gonneaud1, Brigitte Landeau1

  • 1Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000, Caen, France.

Alzheimer'S Research & Therapy
|May 23, 2022
PubMed
Summary
This summary is machine-generated.

Dynamic functional network connectivity (DFNC) states are linked to dementia risk factors. Specific network connection patterns correlate with cognitive activity, biomarkers, and lifestyle choices, potentially explaining cognitive reserve.

Keywords:
Cardiovascular risk factorsCognitionCognitive reserveDementia riskDynamic functional network connectivityLifestyleSliding window analysis

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Biomarkers

Background:

  • Assessing dynamic functional network connectivity (DFNC) in relation to dementia risk is crucial for understanding brain health in aging.
  • Cognitive decline and dementia are significant public health concerns, necessitating research into predictive factors and protective mechanisms.

Purpose of the Study:

  • To investigate the associations between dynamic functional network connectivity (DFNC) and various dementia risk and protective factors in cognitively unimpaired older adults.
  • To explore how different states of functional brain networks relate to cognitive reserve and dementia risk.

Main Methods:

  • Assessed DFNC of the default mode (DMN), salience (SN), and executive control networks in 127 cognitively unimpaired older adults.
  • Employed stepwise regressions with dementia risk factors, protective elements, and biomarkers as predictors of DFNC states.

Main Results:

  • Specific DFNC states showed significant associations: "weakly connected" linked to lower cognitive activity and higher LDL cholesterol; "SN-negatively connected" to higher blood pressure, depression, and lower BMI.
  • "Strongly connected" states correlated with higher cognitive engagement, Preclinical Alzheimer's cognitive composite-5 scores, and BMI.
  • "DMN-negatively connected" states associated with higher stimulating activity engagement and lower LDL cholesterol and blood pressure. Fewer state transitions correlated with reduced brain perfusion.

Conclusions:

  • DFNC states are differentially associated with dementia risk and protective factors.
  • These findings suggest that DFNC patterns may play a role in underlying cognitive reserve.
  • Understanding these relationships can inform strategies for dementia prevention and risk assessment.