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Long lasting immunity in trichinellosis - insight from a small study group
N Ilic1, S Vasilev1, A Gruden-Movsesijan1
1National Reference Laboratory for Trichinellosis (NRLT), Department for Immunology and Immunoparasitology, Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Journal of Helminthology
|May 24, 2022
Summary
Chronic trichinellosis, caused by the parasite Trichinella spiralis, can persist for years, leading to prolonged muscle pain and weakness. This study supports the existence of chronic symptoms, potentially linked to acute infection severity.
Area of Science:
- Parasitology
- Immunology
- Infectious Diseases
Background:
- Trichinellosis, caused by Trichinella spiralis, presents with varied symptoms, and its chronic nature remains debated.
- While acute symptoms often resolve, persistent muscle pain and weakness can last for years.
Purpose of the Study:
- To investigate long-term immunoserological, biochemical, and symptomatic parameters in patients with chronic trichinellosis.
- To assess the persistence of anti-Trichinella antibodies and chronic symptoms following infection.
Main Methods:
- Analysis of twelve patients from two Serbian outbreaks (Kumane and Belgrade) 13-18 years post-infection.
- Assessment of specific anti-Trichinella antibodies and evaluation of persistent myalgia and functional limitations.
Main Results:
- 83% of patients showed persistent specific anti-Trichinella antibodies, with humoral response lasting up to two decades.
- A majority of patients from the Kumane outbreak (7/9) experienced chronic muscular pain and limitations in daily activities for over a decade.
Conclusions:
- The study provides evidence supporting the existence of chronic trichinellosis as a distinct clinical entity.
- Persistent symptoms and limitations may be associated with the severity of the initial acute infection.
