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Updated: Sep 22, 2025

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
[CHEMOTHERAPY FOR CANCER PATIENTS - ARE WE CHOOSING WISELY?]
Natan R Kahan1,2, Dan Andrei Waitman2,3, Pesach Shvartzman4,5,6,7
1Department of Health Promotion, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Chemotherapy near the end of life is common, but palliative care referrals decrease significantly when aggressive treatment is given shortly before death. Oncologists should be more aware of potentially futile end-of-life cancer care.
Area of Science:
- Oncology
- Palliative Care
- Health Services Research
Background:
- The American Society of Clinical Oncology highlights non-evidence-based chemotherapy as futile care.
- Chemotherapy administration in the last month of life is a key quality indicator in oncology.
Purpose of the Study:
- To characterize chemotherapy use and palliative care services in the final year of life for cancer patients.
- To analyze healthcare utilization among terminally ill cancer patients in an Israeli Health Maintenance Organization (HMO).
Main Methods:
- A cross-sectional study analyzed data from 2,617 cancer patients who died between 2009-2013 in Leumit Health Services (LHS).
- Patients were stratified based on the time between their last chemotherapy treatment and death.
- Demographics, morbidity, healthcare utilization, and palliative care referrals in the last six months of life were compared.
Main Results:
- 18.8% of patients received chemotherapy within 14 days of death.
- Palliative care referrals were lowest (15.8%) for patients receiving chemotherapy 0-14 days before death.
- Referrals were highest (31.9%) for those whose last chemotherapy was ≥180 days before death (P<0.0001).
Conclusions:
- Chemotherapy administration near the end of life is inversely associated with palliative care utilization.
- Increased awareness among oncologists regarding potentially futile aggressive treatments in the final weeks of life is crucial.
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