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Updated: Sep 22, 2025

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Convenient Routes to Efficiently N-PEGylated Peptides
Christian Stutz1, Anna Meszynska2, Jean-François Lutz2
1Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, Berlin 12489, Germany.
Abstract:
Efficient routes to N-terminal PEGylated peptides are described. Alternative supports such as superparamagnetic core-shell nanoparticles as colloidal supports and end-functional poly(styrene) as homogeneous supports improve the available solid-phase supported coupling strategies preserving ease of purification. Poly(ethylene glycol) (PEG)-peptide bioconjugates are obtained in high yield despite the use of nearly stoichiometric PEGylation agents with respect to the supported peptides.

