Immunological Changes Associated with Chronic Ingestion of Depleted Uranium in Rats

The objective of this study was to evaluate the effect of depleted uranium (DU) on the rat immune system. Three-wk-old, specific pathogen-free Sprague-Dawley rats that received dietary DU for 4 mo were divided into four groups (30 rats per group) according to exposure dose: 0 (control group), 1.3 (DU1.3 group), 13 (DU13 group), and 130 mg U kg-1 (DU130 group). After 4 mo of exposure, the splenic tissues of the rats presented elevated uranium content in accordance with increasing dosage. The rats in the DU130 group exhibited immunological damage characterized by pathomorphological changes of immune organs and significantly lower thymic and splenic relative weight, whereas the influences of DU on the immune system were slight in the other groups. In addition, higher uranium exposure also resulted in reduced numbers of peripheral lymphocytes, lower lymphocyte proliferation, and reduced paw swelling. The authors concluded that the influences of DU on the immune system were slight after ingestion of DU at lower doses but severe after exposure to DU at higher doses.