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Published on: May 30, 2025
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Long non-coding RNAs in virus-related cancers.
Yushan Huang1, Longchang Jiang2,3, Yang Liu4
1School of Public Health, Lanzhou University, Lanzhou, China.
Reviews in Medical Virology
|May 24, 2022
Summary
Long non-coding RNAs (lncRNAs) play a role in virus-related cancers by regulating gene expression and other cellular processes. This review explores their mechanisms in cancers caused by Hepatitis B virus, Epstein-Barr virus, and Human Papillomavirus, including potential roles in COVID-19.
Area of Science:
- Molecular Biology
- Oncology
- Virology
Background:
- Viral infections are a known cause of cancer through various molecular pathways.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in biological functions and disease.
- lncRNAs can influence gene expression, protein modification, and interactions with nucleic acids and proteins.
Purpose of the Study:
- To review the dysregulation and mechanisms of lncRNAs in virus-associated cancers.
- To focus on cancers linked to Hepatitis B virus (HBV), Epstein-Barr virus (EBV), and Human Papillomavirus (HPV).
- To discuss the potential involvement of lncRNAs in COVID-19 pathogenesis.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of lncRNA functions in viral oncogenesis.
- Exploration of lncRNA roles in specific virus-related cancers (HBV, EBV, HPV) and COVID-19.
Main Results:
- lncRNAs are dysregulated in virus-related cancers.
- Mechanisms include gene alternation, transcriptional regulation, protein modification, and microRNA sponging.
- lncRNAs show potential implications in HBV, EBV, HPV-associated cancers, and COVID-19.
Conclusions:
- lncRNAs are critical regulators in the development of virus-related cancers.
- Understanding lncRNA mechanisms offers potential therapeutic targets.
- Further research into lncRNAs in viral oncogenesis and COVID-19 is warranted.
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