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Integrated Aptasensor Array for Sweat Drug Analysis.

Xiaoyu Zhang1, Yongtao Tang1, Hao Wu1

  • 1College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Guangzhou 510632, China.

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|May 24, 2022
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Summary
This summary is machine-generated.

A new wearable electrochemical aptasensor array can rapidly detect multiple drugs in sweat with high accuracy. This innovation offers a portable solution for daily drug abuse monitoring, overcoming limitations of traditional lab-based methods.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Drug abuse poses significant risks to public health and society.
  • Existing drug detection methods often require complex laboratory equipment and are not suitable for daily, on-site monitoring.
  • There is a critical need for rapid, sensitive, and portable drug detection technologies.

Purpose of the Study:

  • To develop a wearable electrochemical aptasensor array for the sensitive and specific detection of multiple drugs in human sweat.
  • To design aptasensors capable of generating distinct electrochemical fingerprints for various psychoactive drugs and interfering substances.
  • To validate the sensor's performance in artificial and human sweat samples.

Main Methods:

  • Fabrication of a wearable electrochemical aptasensor array utilizing single and dual aptamers with varied base compositions.
  • Employing molecular docking simulations to predict aptamer-bioamine binding affinities.
  • Utilizing extracted electrochemical signal features to differentiate between various analytes.
  • Testing the sensor array with sixteen analytes at different concentrations in artificial and human sweat.

Main Results:

  • The aptasensor array successfully generated distinct electrochemical fingerprints for different drugs and interfering substances.
  • Sixteen analytes were identified with 100% accuracy at both uniform and gradient concentrations.
  • The wearable sensor platform demonstrated the ability to differentiate drugs with similar chemical structures in sweat samples.

Conclusions:

  • The developed wearable electrochemical aptasensor array provides a novel, rapid, and accurate method for on-site drug detection in sweat.
  • This technology overcomes the limitations of traditional laboratory-based drug testing methods.
  • The sensor serves as a valuable platform for developing wearable devices for continuous monitoring of human biochemical information.