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Updated: Sep 22, 2025

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH
Dawei Li1,2, Yueqi Leng3, Zhengzheng Liao4
1Department of Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, People's Republic of China.
Abstract:
Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4-6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (1-6) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of 70.27%. In addition, the cytotoxic effect of compounds (1-6) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity.
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