Indolent lymphadenopathic Kaposi's sarcoma

Kaposi's sarcoma is usually an indolent skin neoplasm. Diffuse lymph node and visceral involvement have been described in young African patients and in patients who are immunosuppressed; in such patients the disease is usually rapidly progressive. We describe the case of a 64-year-old man of Italian ancestry with diffuse lymph node involvement by Kaposi's sarcoma in the absence of any skin lesions. The patient had no evidence of immunosuppression. The course has been indolent, with no disease progression over 2 years of follow-up on no therapy.