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Two-step aberration correction: application to transcranial histotripsy.

Ning Lu1, Timothy L Hall1, Jonathan R Sukovich1

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, United States of America.

Physics in Medicine and Biology
|May 24, 2022
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Summary

This study enhances aberration correction for transcranial histotripsy by combining CT-based and acoustic cavitation emission methods. The improved 2-step approach significantly refines focal accuracy for brain therapy.

Keywords:
aberration correctioncavitation shockwavescomputed tomographyhistotripsytranscranial ultrasound

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Area of Science:

  • Medical Physics
  • Acoustic Imaging
  • Neurosurgery

Background:

  • Transcranial histotripsy requires accurate focusing through the skull.
  • Skull bone heterogeneity causes significant focal distortion.
  • Existing aberration correction methods have limitations in clinical settings.

Purpose of the Study:

  • To improve a 2-step aberration correction (AC) method for transcranial histotripsy.
  • To develop a clinically applicable AC workflow.
  • To compensate for focal distortion caused by skull bone heterogeneity.

Main Methods:

  • Implemented a 2-step AC workflow: computed tomography (CT)-based analytical approach followed by acoustic cavitation emission (ACE)-based approach.
  • Utilized a 700 kHz, 360-element hemispherical transducer array for cavitation generation and ACE shockwave acquisition.
  • Investigated forward and backward ray-tracing models for CT-based AC and cross-correlation for ACE-based AC.

Main Results:

  • The 2-step AC achieved 90 ± 7% peak focal pressure compared to hydrophone correction.
  • Reduced average focal shift from 0.84 mm to 0.30 mm.
  • Decreased average focal volume from 10.6 mm³ to 2.0 mm³ compared to no AC.

Conclusions:

  • The 2-step AC method provides superior refocusing compared to CT-AC or ACE-AC alone.
  • This improved method can be implemented in real-time for transcranial histotripsy.
  • The workflow is suitable for clinical application in brain therapy.