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Updated: Sep 22, 2025

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Published on: July 21, 2021
The multiple roles and therapeutic potential of HSP60 in cancer
Yaoxiang Tang1, Ying Zhou1, Songqing Fan1
1Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Abstract:
The molecular chaperone protein HSP60 is mainly distributed in mitochondria and assists protein folding under physiological and pathological conditions. Accumulating evidence suggests abnormally expressed HSP60 in cancer is associated with clinicopathological features and prognosis of cancer patients. HSP60 could be used as a new biomarker for both diagnostic and prognostic purpose and tumor therapy. In this review article, we briefly described the structure, functional cycle, and regulatory mechanism of HSP60, and summarized its functional diversity in cancer as well as recent progress related to the diagnostic application of HSP60 and inhibitors against HSP60, which could provide us a comprehensive understanding about the value of HSP60 in tumor management.
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