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Lurasidone-induced hyperosmolar hyperglycemic syndrome: A case report
Shota Hanyu1, Yusuke Kojima2, Toshiya Murai1
1Department of Psychiatry, Kyoto University Hospital, Kyoto, Japan.
Neuropsychopharmacology Reports
|May 24, 2022
Summary
Lurasidone, an antipsychotic, can rarely cause severe hyperglycemia. Early blood glucose monitoring is crucial for detecting and managing this rare but serious side effect, preventing complications.
Area of Science:
- Pharmacology
- Endocrinology
- Psychiatry
Background:
- Lurasidone is an atypical antipsychotic with a generally favorable metabolic profile.
- It is often chosen for patients at risk of weight gain or glucose dysregulation from other antipsychotics.
Observation:
- An 81-year-old male patient with bipolar disorder developed hyperosmolar hyperglycemic syndrome (HHS).
- This severe hyperglycemic state was identified as a rare adverse effect of lurasidone treatment.
Findings:
- The case highlights a rare but potentially fatal complication of lurasidone, namely HHS.
- Routine blood glucose monitoring facilitated early diagnosis and intervention, averting life-threatening outcomes.
Implications:
- Despite lurasidone's low risk for hyperglycemia, vigilance is necessary.
- Regular monitoring of blood glucose levels in patients on lurasidone is recommended to detect early signs of hyperglycemia and prevent severe complications like HHS.
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