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Updated: Sep 22, 2025

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
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Dali server: structural unification of protein families

Liisa Holm1

  • 1Institute of Biotechnology, Helsinki Institute of Life Sciences, and Organismal and Evolutionary Biology Research Program, Faculty of Biosciences, University of Helsinki, Finland.

Nucleic Acids Research
|May 24, 2022
PubMed

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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